Procalcitonin as New Proinflammatory Marker in Burn Patients

Authors

Amer A. Khaleel, Department of Medical Microbiology, College of Health Sciences, Hawler Medical University, Erbil, Kurdistan Region, IraqFollow
Ruqaya M. Al-Barzinji, Hawler Medical University

Corresponding Author

Amer A. Khaleel

Authors ORCID

0000-0002-9405-2658

Document Type

Research Article

Abstract

Procalcitonin (PCT) is a 116 amino acid peptide with a sequence identical to that of prohormone of calcitonin but devoid of hormonal activity. The aim of this study was to determine PCT and it using as a new prognostic pro-inflammatory marker in burn patients and determine the role of PCT level as a mortality indicator in survival and non-survival burn patients. The burn patients in this study were divided into four groups according to the percentage of total body surface area burned carry out on (50) burn patients admitted to the burn unit in West Erbil Emergency Hospital in Erbil governorate and (20) apparently the healthy non-burn individuals who regarded as healthy control group (HC) in this study from February 2012 to April 2012. Out of 50 burnt patients, 20 patients were second sampled to follow-up their immune profile. Regarding PCT there were significant differences (P < 0.05) observed between the mean serum concentration of PCT belong to 18 burn patients of 1st group (G1) (1.24 ± 0.82), 23 patients of 2nd group (G2) (1.52 ± 0.76), six patients of 3rd group (G3) (2. 16 ± 0.11), and three burn patients of 4th group (G4) (6.5 ± 2.87) with mean serum concentration of 18 HC (0.02 ± 0.006). Significant differences obtained when compared to G3 (2.16 ± 0.11) versus G4 (6.5 ± 2.87) using the F-test and t-test. Results show that PCT is a highly productive laboratory parameter involving an easy and rapid beside test for diagnosis and prognosis mortality in burn patients.

Keywords

Procalcitonin, Total body surface area, Burn patient

How to Cite This Article

Khaleel, Amer A. and Al-Barzinji, Ruqaya M. (2021) "Procalcitonin as New Proinflammatory Marker in Burn Patients," Polytechnic Journal: Vol. 11: Iss. 1, Article 12.
DOI: https://doi.org/10.25156/ptj.v11n1y2021.pp58-62

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Publication Date

6-30-2021