The Dissolution enhancement of Meloxicam tablets from the synergistic effect of hydrotropic and sublimating agent

Hemn L. Qader, Department of pharmaceutics, College of pharmacy, Hawler Medical University, Kurdistan Region, IraqFollow
Tara A. Abdula, Hawler Medical UniversityFollow
Huner K. Omer, Hawler Medical University

Corresponding Author

Hemn L. Qader

Authors ORCID

0000-0001-8817-7465

Document Type

Research Article

Abstract

Background and Objective: Drugs which fall into Class II of Biopharmaceutical Classification System suffer from poor aqueous solubility that limits the dissolution and oral bioavailability. The improvement of the dissolution rate of this class of drug is an important issue for enhancing their bioavailability and therapeutic efficacy. The objective of this study is to investigate the magnitude of enhancement of the dissolution rate of Class II drug “Meloxicam (MLX)” by using more than one solubility enhancement technique.

Keywords

Meloxicam, Solubility, Solid dispersion, Sublimation, camphor

How to Cite This Article

Qader, Hemn L.; Abdula, Tara A.; and Omer, Huner K. (2021) "The Dissolution enhancement of Meloxicam tablets from the synergistic effect of hydrotropic and sublimating agent," Polytechnic Journal: Vol. 11: Iss. 2, Article 16.
DOI: https://doi.org/10.25156/ptj.v11n2y2021.pp100-108