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Corresponding Author

Zekra A. Aziz

Authors ORCID

0000-0002-8644-2939

Document Type

Research Article

Abstract

Rheumatoid Arthritis (RA) is a systemic autoimmune inflammatory disorder that causes joints destruction the aim here is to investigate the neutrophil - to - lymphocyte ratio (NLR) and platelet - to- lymphocyte ratio (PLR) in RA patients and relation to Disease Activity Score of 28 joints (DAS28-ESR). The study population included (260) participants which consist of (210) RA patients and (50) healthy persons as a control. RA patients were two groups (107) received conventional diseases modified anti-rheumatic drugs (cDMARD) and (103) received biological agents (bDMARD) plus cDMARD each group subdivided into disease active patients (DAS28-ESR ≥ 2.6) and patients in remission (DAS28-ESR < 2.6). NLR in cDMARD, bDMARD plus cDMARD, and control group was 3.1 (±3.4), 2.2 (±1.3), and 2.4 (±1.3) respectively. PLR in cDMARD, bDMARD plus cDMARD, and control group was 193.3 (±355.3), 115.7 (±42.7), and 115.6 (±43.1) respectively. There was statistically significant difference in NLR and PLR among three groups (p = 0.023 and p = 0.030) respectively also according to DAS28-ESR in patients with active disease (p = 0.006) for both NLR and PLR, while for patients in remission NLR and PLR there were no significant differences detected (p = 0.901 and p = 0.638 respectively). The result of the current study support the idea that NLR and PLR can be considered as inflammatory parameters for evaluating disease activity in RA patients.

Keywords

Rheumatoid arthritis, Disease activity, Neutrophil, Platelet, Lymphocyte

Publication Date

6-14-2022

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