The Ketogenic Diet Effect On Organ Chemistries

Authors

Rundk Hwaiz, Department of Nutrition and Dietetics, College of Health Sciences, Hawler Medical University, Kurdistan Region of Iraq
Mohammad Mostafa, Department of Nutrition and Dietetics, College of Health Sciences, Hawler Medical University, Kurdistan Region of Iraq
Sazan Talaat, Department of Nutrition and Dietetics, College of Health Sciences, Hawler Medical University, Kurdistan Region of IraqFollow
Mohammed Merza, Department of Clinical analysis, College of Pharmacy, Hawler Medical University, Kurdistan Region of Iraq

Corresponding Author

Rundk Hwaiz

Authors ORCID

0000-0003-4480-4077

Document Type

Original Article

Abstract

Background: ketogenic diet refers to the diet plan that emphasizes foods that are high in fats, moderate proteins and very low carbohydrates to consume more calories from fat rather than carbohydrates and is commonly used as a weight-loss plan and in rare cases, as a treatment for some diseases. Objective: The aim of this study was to evaluate or assess organ functions in the individuals following ketogenic diet. Patients and methods: A total 31 samples were collected from individuals following ketogenic diet in male and femal aged from 20 to 55, and a control group which composed of 10 healthy individuals without ketogenic diet, and the diet duration was from 2 to 44 weeks. The sample were collected from Dec 2021 to Mar 2021 at Rozhalat emergency laboratory. We have measured serum urea, creatinine and hepatic enzymes in those individuals. We measured it statistically and regarded p-value for significance for less than 0.05. Result: Our result showed that ketogenic diet reduced the estimated glomerular filtration rate (eGFR) and induced Alanine transaminase(ALT) compared to control group (individual without ketogenic diet), moreover, there is no statistically difference in serum Aspartate transaminase(AST) and bilirubin compared to control group. The mean value of eGFR, ALT, AST, and bilirubin in ketogenic group are (79.3±5.7), (22.7± 3.6), (24.87±3.73), (0.72±0.05) respectively. Conclusion: We have observed that ketogenic diet affects the kidney function, the function of other organs like liver and induce hypercholesterolemia

Keywords

Ketogenic diet; kidney function; liver; lipid profile; cholesterol.

How to Cite This Article

Hwaiz, Rundk; Mostafa, Mohammad; Talaat, Sazan; and Merza, Mohammed (2023) "The Ketogenic Diet Effect On Organ Chemistries," Polytechnic Journal: Vol. 13: Iss. 2, Article 3.
DOI: https://doi.org/10.59341/2707-7799.1718

References

[1] Kirkpatrick CF, Bolick JP, Kris-Etherton PM, Sikand G, Aspry KE, Soffer DE, et al. Review of current evidence and clinical recommendations on the effects of low-carbohydrate and very-low-carbohydrate (including ketogenic) diets for the management of body weight and other cardiometabolic risk factors: a scientific statement from the National Lipid Association Nutrition and Lifestyle Task Force. J Clin Lipidol 2019; 13(5):689e711.e1. https://doi.org/10.1016/j.jacl.2019.08.003.

[2] Batch JT, Lamsal SP, Adkins M, Sultan S, Ramirez MN. Advantages and disadvantages of the ketogenic diet: a review article. Cureus 2020;12(8):e9639. https://doi.org/10. 7759%2Fcureus.9639.

[3] Kim JM. Ketogenic diet: old treatment, new beginning. Clin Neurophysiol Pract 2017;2:161e2. https://doi.org/10.1016% 2Fj.cnp.2017.07.001.

[4] Sharman MJ, Volek JS. Weight loss leads to reductions in inflammatory biomarkers after a very-low-carbohydrate diet and a low-fat diet in overweight men. Clin Sci (Lond) 2004; 107(4):365e9. https://doi.org/10.1042/cs20040111.

[5] Monda V, Polito R, Lovino A, Finaldi A, Valenzano A, Nigro E, et al. Short-term physiological effects of a very lowcalorie ketogenic diet: effects on adiponectin levels and inflammatory states. Int J Mol Sci 2020;21(9). https://doi.org/10. 3390%2Fijms21093228.

[6] Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001;7(8):941e6. https://doi.org/10.1038/ 90984.

[7] Dupuis N, Curatolo N, Benoist JF, Auvin S. Ketogenic diet exhibits anti-inflammatory properties. Epilepsia 2015;56(7): e95e8. https://doi.org/10.1111/epi.13038.

[8] Gershuni VM, Yan SL, Medici V. Nutritional ketosis for weight management and reversal of metabolic syndrome. Curr Nutr Rep 2018;7(3):97e106. https://doi.org/10.1007% 2Fs13668-018-0235-0.

[9] Achari AE, Jain SK. Adiponectin, a therapeutic target for obesity, diabetes, and endothelial dysfunction. Int J Mol Sci 2017;18(6). https://doi.org/10.3390/ijms18061321.

[10] Mundi MS, Mohamed Elfadil O, Patel I, Patel J, Hurt RT. Ketogenic diet and cancer: fad or fabulous? JPEN J Parenter Enteral Nutr 2021;45(S2):26e32. https://doi.org/10.1002/jpen. 2226.

[11] Weber DD, Aminazdeh-Gohari S, Kofler B. Ketogenic diet in cancer therapy. Aging (Albany NY) 2018;10(2):164e5. https:// doi.org/10.18632%2Faging.101382.

[12] Morscher RJ, Aminzadeh-Gohari S, Feichtinger RG, Mayr JA, Lang R, Neureiter D, et al. Inhibition of neuroblastoma tumor growth by ketogenic diet and/or calorie restriction in a CD1-Nu mouse model. PLoS One 2015;10(6): e0129802. https://doi.org/10.1371/journal.pone.0129802.

[13] Klement RJ. Beneficial effects of ketogenic diets for cancer patients: a realist review with focus on evidence and confirmation. Med Oncol 2017;34(8):132. https://doi.org/10. 1007/s12032-017-0991-5.

[14] Liskiewicz AD, Kasprowska D, Wojakowska A, Polanski K, Lewin-Kowalik J, Kotulska K, et al. Long-term high fat ketogenic diet promotes renal tumor growth in a rat model of tuberous sclerosis. Sci Rep 2016;6:21807. https://doi.org/10. 1038/srep21807.

[15] Klement RJ, Schafer G, Sweeney RA. A ketogenic diet exerts beneficial effects on body composition of cancer patients during radiotherapy: an interim analysis of the KETOCOMP study. J Tradit Complement Med 2020;10(3):180e7. https:// doi.org/10.1016/j.jtcme.2019.03.007.

[16] Iyikesici MS, Slocum AK, Slocum A, Berkarda FB, Kalamian M, Seyfried TN. Efficacy of metabolically supported chemotherapy combined with ketogenic diet, hyperthermia, and hyperbaric oxygen therapy for stage IV triplenegative breast cancer. Cureus 2017;9(7):e1445. https://doi. org/10.7759/cureus.1445.

[17] Masood W, Annamaraju P, Uppaluri KR. Ketogenic Diet. StatPearls. Treasure Island (FL) ineligible companies. Disclosure: Pavan Annamaraju declares no relevant financial relationships with ineligible companies. Disclosure: Kalyan Uppaluri declares no relevant financial relationships with ineligible companies. 2023. Available from: http://www.ncbi. nlm.nih.gov/books/nbk499830/.

[18] Bathum L, Petersen HC, Rosholm JU, Hyltoft Petersen P, Vaupel J, Christensen K. Evidence for a substantial genetic influence on biochemical liver function tests: results from a population-based Danish twin study. Clin Chem 2001;47(1): 81e7. https://doi.org/10.1093/clinchem/47.1.81.

[19] Hsu CY, Yang W, Parikh RV, Anderson AH, Chen TK, Cohen DL, et al. Race, genetic ancestry, and estimating kidney function in CKD. N Engl J Med 2021;385(19):1750e60. https://doi.org/10.1056/nejmoa2103753.

[20] Masood W, Annamaraju P, Khan Suheb MZ, et al. Ketogenic diet. [Updated 2023 Jun 16]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK499830/.

[21] Chang MH, Ned RM, Hong Y, Yesupriya A, Yang Q, Liu T, et al. Racial/ethnic variation in the association of lipidrelated genetic variants with blood lipids in the US adult population. Circ Cardiovasc Genet 2011;4(5):523e33. https:// doi.org/10.1161/circgenetics.111.959577.

[22] Alexander SC, Cox ME, Yancy WS, Boling Turer C, Lyna P, Ostbye T, et al. Weight-loss talks: what works (and what doesn’t). J Fam Pract 2011;60(4):213e9. https://pubmed.ncbi. nlm.nih.gov/26048291.

[23] Chung JY, Kim OY, Song J. Role of ketone bodies in diabetes-induced dementia: sirtuins, insulin resistance, synaptic plasticity, mitochondrial dysfunction, and neurotransmitter. Nutr Rev 2022;80(4):774e85. https://doi.org/10.1093/nutrit/ nuab118.

[24] Weber DD, Aminzadeh-Gohari S, Tulipan J, Catalano L, Feichtinger RG, Kofler B. Ketogenic diet in the treatment of cancer e Where do we stand? Mol Metab 2020;33:102e21. https://doi.org/10.1016/j.molmet.2019.06.026.

[25] Zhang W, Guo X, Chen L, Chen T, Yu J, Wu C, et al. Ketogenic diets and cardio-metabolic diseases. FrontEndocrinol (Lausanne) 2021;12:753039. https://doi.org/10. 3389/fendo.2021.753039.

[26] Crosby L, Davis B, Joshi S, Jardine M, Paul J, Neola M, et al. Ketogenic diets and chronic disease: weighing the benefits against the risks. Front Nutr 2021;8:702802. https://doi.org/10. 3389/fnut.2021.702802.

[27] Musso CG, Alvarez Gregori J, Jauregui JR, Macias Nunez JF. Creatinine, urea, uric acid, water and electrolytes renal handling in the healthy oldest old. World J Nephrol 2012; 1(5):123e6. https://doi.org/10.5527%2Fwjn.v1.i5.123.

[28] Olde Damink SW, Jalan R, Dejong CH. Interorgan ammonia trafficking in liver disease. Metab Brain Dis 2009;24(1): 169e81. https://doi.org/10.1007/s11011-008-9122-5.

[29] Griffin JWD, Bradshaw PC. Effects of a high protein diet and liver disease in an in silico model of human ammonia metabolism. Theor Biol Med Model 2019;16(1):11. https://doi. org/10.1186/s12976-019-0109-1.

[30] Anekwe CV, Chandrasekaran P, Stanford FC. Ketogenic diet-induced elevated cholesterol, elevated liver enzymes and potential non-alcoholic fatty liver disease. Cureus 2020; 12(1):e6605. https://doi.org/10.7759/cureus.6605.

[31] Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Saturated fatty acids and risk of coronary heart disease: modulation by replacement nutrients. Curr Atheroscler Rep 2010;12(6):384e90. https://doi.org/10.1007/s11883-010- 0131-6.