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Corresponding Author

Goran Qader Othman

Document Type

Research Article

Abstract

The hypotriglyceridemic potentials of dietary consumption of hawthorn (dried Crataegus spinnatifida.) were investigated by monitoring serum lipid and liver function tests in Sprague-Dawley rats. Thirty rats were randomly divided in 3 groups that received either normal food diet (NFD), high-triglyceride diet (HTD) or hypertriglyceridemia supplemented with hawthorn powder (2%, w/w) for 5 weeks. The level of triglyceride (TG) total cholesterol and liver function enzymes Including alkaline phosphatase (ALP), serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic-pyruvic transaminase (SGPT) were measured. The results recorded elevated fasting serum triglyceride and cholesterol levels in HTD, while consumption of hawthorn markedly and significantly suppressed these elevations in triglyceride and cholesterol. On the other hand, the liver enzymes such as ALP, SGOT and SGPT were slightly lower after consumption of hawthorn. The histological sections of hypertriglyceridemia rat’s liver revealed accumulation of lipid deposition, loss of hepatocytes integrity, hepatocytes enlargement and infiltration of the mononuclear cells and congestion of the blood vessels, while hawthorn administration resulted in recovery of theses alteration that were comparable with the control group. Our findings suggest that hawthorn leaf powder is capable of significant reduction in triglyceride and might have a protective role in liver due to the lowering of the liver transaminase levels and retrieval of the hepatic cell morphology in Sprague-Dawley rats.

Keywords

Hawthorn, Hyper-triglyceridemia, Liver function, rats

Publication Date

6-1-2017

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