New Batch and Flow Injection Spectrophotometric Method for Determination of Captopril in Same Pharmaceutical Products

Authors

Yousif Taha Rasool, Department of Petroleum Technology, Erbil Technical Institution, Erbil Polytechnic University, Iraq
Shirwan O. Baban, Department of Chemistry, Collage of education,salahaddin University

How to Cite This Article

Rasool, Yousif Taha and Baban, Shirwan O. (2018) "New Batch and Flow Injection Spectrophotometric Method for Determination of Captopril in Same Pharmaceutical Products," Polytechnic Journal: Vol. 7: Iss. 2, Article 5.
DOI: https://doi.org/10.25156/ptj.2018.8.2.142

Document Type

Original Article

Abstract

ABSTRACT A simple, new, inexpensive and sensitive batch and flow injection spectrophotometric methods for determination of captopril in pharmaceutical products. The procedure was based on oxidationreduction reaction between of captopril with a known excess of bromine solution in acidic medium. Bromine solution in acid medium decolorize the Rhodamine B dye. A known excess of bromine in acidic medium treated with captopril followed by spectrophotometric determination of unreacted bromine, unreacted bromineby reacting with a fixed amount of Rodamine B dye at 555 nm. . Beer’s law was obeyed in the concentration ranges 0.3-2.3 μg mL-1 with detection limits 0.018 μg mL-1. The molar absorptivity and correlation coefficients (r) were 1.4x105 l/mol.cm, 0.9992 for batch method. The calibration graph constructed for FI method, obeyed Beer’s law in the concentration range (1-6 μg mL-1) with a molar absorptivity 2.1x104l/mol.cm, limit of detection 0.3 μg mL-1, correlation coefficient (r) 0.9987, , and sampling frequency 90 determinations per hour.

Publication Date

5-1-2018

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