Estimation of Serum Homeostasis Model Assessment-Insulin Resistance and Lipid Profile in Beta-thalassemia Major Patients and their Correlation with Iron Overload in Koya City

Kochar K. Saleh, Department of Community Health,Koya Technical Institute, Erbil Polytechnic UniversityFollow
Saman R. Abdullah, Department of Civil EngineeringFollow
Rukhosh E. Mekha, Erbil Polytechnic University, Erbil, Kurdistan Region ,IraqFollow

Corresponding Author

Kochar K. Saleh

Authors ORCID

0000-0002-5175-8431

Document Type

Research Article

Abstract

The current study focused on 43 patients who suffer from major beta-thalassemia at the hospital of shaheed Dr. Khaled in the Koya city. Out range, age of cases was 8.03 ± 4.0 and of controls was 7.81 ± 3.11 years. Our aim is to observe the prevalence of homeostasis model assessment-insulin resistance and other physiological and biochemical changes in major beta-thalassemia. While we a significant changes confirm that serum glucose concentration was significantly higher in the patients than in the controls (P ? 0.01) and lipid abnormality occurs in beta-thalassemia major patients, which include high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), serum total cholesterol (TC), serum triglycerides (TG), and very-low-density lipoprotein (VLDL) levels compared with normal healthy controls. There was no significant difference between the serum insulin level of cases and controls (P = 0.214), the mean values of serum HDL-C, LDL-C, TC, TG, and VLDL in cases were 29.5 ± 7.8, 65.2 ± 1.9, 121.9 ± 36.7, 182.09 ± 43.1, and 26.47 ± 12.13 mg/dl, respectively. Moreover, the mean values of serum HDL-C, LDL-C, TC, TG, and VLDL in controls were 48.6 ± 4.2, 79.7 ± 14.5, 178.7 ± 14.6, 124.14 ± 12.1, and 23.52 ± 5.47 mg/dl, respectively. In conclusion, the results suggested that revealed that beta-thalassemia patients had hypertriglyceridemia, hypocholesterolemia, and low LDL-C, and HDL-C levels.

Keywords

Homeostasis model assessment-insulin resistance, Lipid profile and iron overload, Major beta-thalassemia

How to Cite This Article

Saleh, Kochar K.; Abdullah, Saman R.; and Mekha, Rukhosh E. (2019) "Estimation of Serum Homeostasis Model Assessment-Insulin Resistance and Lipid Profile in Beta-thalassemia Major Patients and their Correlation with Iron Overload in Koya City," Polytechnic Journal: Vol. 9: Iss. 2, Article 21.
DOI: https://doi.org/10.25156/ptj.v9n2y2019.pp125-132