Simultaneous Determination of Atenolol and Amlodipine Using Second Derivative Spectroscopy

Muharram Y. Mohammad, Department of Medical Lab Technology,Erbil Medical Institute, Erbil Technical UniversityFollow
Mohammad S. Abdullah, Department of Chemistry, College of Education
Sangar S. Sabir, Erbil Technical UniversityFollow

Corresponding Author

Muharram Y. Mohammad

Authors ORCID

0000-0001-9262-3640

Document Type

Research Article

Abstract

The present study describes employing second derivative spectrophotometry for simultaneous determination of atenolol and amlodipine in pure form and in commercial formulations. The method is simple, accurate, precise and economic. Zero crossing point technique was used for analysis of the drugs in the combined formulation. The method was found to be linear in the concentration range 5.0-50.0µg/ml of atenolol at 251nm and 5.0-45.0µg/ml of amlodipine at 264nm. The proposed method was successfully applied to determine atenolol and amlodipine in combined dosage as well as in a separate dosage. The obtained results were in good agreement with standard method.

Keywords

Atenolol, Amlodipine, Second derivative spectroscopy

How to Cite This Article

Mohammad, Muharram Y.; Abdullah, Mohammad S.; and Sabir, Sangar S. (2019) "Simultaneous Determination of Atenolol and Amlodipine Using Second Derivative Spectroscopy," Polytechnic Journal: Vol. 9: Iss. 2, Article 5.
DOI: https://doi.org/10.25156/ptj.v9n2y2019.pp25-29