Nephroprotective Roles of L-Cysteine, Silymarin and Ursodeoxycholic acid, against Carbon Tetrachloride induced Nephrotoxicity in Male Albino Rats

Hero H. Muhammed Saed Mrs., Chemistry Department, College of Education, University of Garmian, Kalar, Kurdistan Region, Iraq
Sarwar N. Jafar Mr., Biology Department, College of Education, University of Salahaddin, Erbil, Kurdistan Region, Iraq
Zeyan A. Ali Mrs., Chemistry Department, College of Education, University of Salahaddin, Erbil, Kurdistan Region, IraqFollow
Treefa F. Ismail Mrs., Biology Department, College of Education, University of Salahaddin, Erbil, Kurdistan Region, Iraq

Corresponding Author

Hero H. Muhammed Saed

Document Type

Research Article

Abstract

The comparison of histopathological and biochemical effects of L-cysteine, silymarin and ursodeoxycholic acid which have a protective effect on kidney function against CCl4 induce nephrotoxicity were investigated in this study. Twenty adult male rats were divided into 5 groups and treated as follows, the control group was administrated 1.5 ml/kg. B.W physiological solution (0.9%) orally, Carbon Tetrachloride group (CCl4 1.5 ml/kg. B.W), L-cysteine (100mg/kg B.W.) +CCl4 group, ursodeoxycholic acid (50 ml/kg B.W.) +CCl4 group, and the last group was Silymarin 100 mg/kg. B.W with CCl4, the experiment lasted 30 days. Oxidative stress caused by CCl4 caused increasing in Creatinine and Urea levels in serum while decreasing the level of uric acid and albumin when compared with the control group, L-cysteine, Silymarin and the drug presented ameliorating effect by decreasing creatinine, Urea, and increasing the level of uric acid with albumin. Histopathological results showed that CCl4 caused oxidative damage in kidney tubules in comparison with control group, while Silymarin, L-cysteine showed nephroprotective effects

Keywords

L-cysteine, Silymarin, CCl4, Kidney, Oxidative stress, Rats

How to Cite This Article

Saed, Hero H. Muhammed Mrs.; Jafar, Sarwar N. Mr.; Ali, Zeyan A. Mrs.; and Ismail, Treefa F. Mrs. (2023) "Nephroprotective Roles of L-Cysteine, Silymarin and Ursodeoxycholic acid, against Carbon Tetrachloride induced Nephrotoxicity in Male Albino Rats," Polytechnic Journal: Vol. 13: Iss. 1, Article 15.
DOI: https://doi.org/10.59341/2707-7799.1739