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Corresponding Author

Shukur Wasman Smail

Document Type

Research Article

Abstract

Background and objectives: Coronary heart disease (CHD) is one of the most prevalent diseases worldwide. The primary risk factor for coronary heart disease (CHD) lies in the presence of hypertension, elevated levels of triglycerides (TG), total cholesterol (TC), and low-density lipoprotein (LDL) in the bloodstream. Furthermore, a reduction in high-density lipoprotein (HDL) levels is linked to an elevated risk of cardiovascular disease-related mortality.

The current retrospective study was undertaken to evaluate the alterations in the lipid profile of patients with CHD.

Methods: The current survey involved collecting data from 867 patients diagnosed with acute or severe CHD, with an average age of 48.38± 0.503. In addition, the study included 850 healthy controls whose average age was 47.22±1.234. The serum levels of TC, HDL, LDL, and TG were obtained from Zanko Hospital in Erbil city, Iraq. The comparison between the recorded parameters of healthy controls and patients was conducted using the t-test function in GraphPad Prism 6.0.

Results: The lipid profile consisted of measurements for TC, LDL, HDL, and TG. The TC levels were notably higher in cases of CHD in individuals under 40 years old compared to controls. Moreover, there was a notable rise in TG levels among individuals with CHD aged 40-60, in contrast to the control group. Conversely, there was no significant difference in the levels of HDL and LDL between the cases and control group.

Conclusions: There was a significant difference in TC and TG levels between cases and controls in certain groups, while other lipid profiles did not show significant changes.

Keywords

Cardiovascular disease, Cholesterol, Coronary Heart Diseases, Lipid Profile, Triglycerides

References

ACARTÜRK, E., CAYLI, M., AKPINAR, O., ATTILA, G. & DEMIR, M. 2004. Relation between age and gender differences in plasma triglyceride concentrations and coronary artery disease in Southern Turkey. Clin Chim Acta, 339, 123-8.

BANDERALI, G., CAPRA, M. E., BIASUCCI, G., STRACQUADAINO, R., VIGGIANO, C. & PEDERIVA, C. 2022. Detecting Familial hypercholesterolemia in children and adolescents: potential and challenges. Ital J Pediatr, 48, 115.

BJÖRNSON, E., ADIELS, M., TASKINEN, M. R., BURGESS, S., RAWSHANI, A., BORÉN, J. & PACKARD, C. J. 2023. Triglyceride-rich lipoprotein remnants, low-density lipoproteins, and risk of coronary heart disease: a UK Biobank study. Eur Heart J, 44, 4186-4195.

BONOW, R. O., CARABELLO, B. A., CHATTERJEE, K., DE LEON, A. C., FAXON, D. P., FREED, M. D., GAASCH, W. H., LYTLE, B. W., NISHIMURA, R. A. & O’GARA, P. T. 2006. ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (writing Committee to Revise the 1998 guidelines for the management of patients with valvular heart disease) developed in collaboration with the Society of Cardiovascular Anesthesiologists endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. Journal of the American College of Cardiology, 48, e1-e148.

BOUDOULAS, K. D., TRIPOSCIADIS, F., GELERIS, P. & BOUDOULAS, H. 2016. Coronary Atherosclerosis: Pathophysiologic Basis for Diagnosis and Management. Prog Cardiovasc Dis, 58, 676-92.

CASTELLI, W. P., ANDERSON, K., WILSON, P. W. & LEVY, D. 1992. Lipids and risk of coronary heart disease The Framingham Study. Annals of epidemiology, 2, 23-28.

COLLABORATION, A. P. C. S. 2005. Joint effects of systolic blood pressure and serum cholesterol on cardiovascular disease in the Asia Pacific region. Circulation, 112, 3384- 90.

DAI, L., LI, R., HAO, Q., BAO, Y., HU, L., ZHANG, Y., KANG, H., WU, H., MA, X. & SONG, Y. 2023. Breast cancer is associated with coronary heart disease: a cross-sectional survey of NHANES 1999-2018. Front Cardiovasc Med, 10, 1274976.

FRIEDEWALD, W. T., LEVY, R. I. & FREDRICKSON, D. S. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical chemistry, 18, 499-502.

GAZIANO, T. A., BITTON, A., ANAND, S., ABRAHAMS-GESSEL, S. & MURPHY, A. 2010. Growing epidemic of coronary heart disease in low-and middle-income countries. Current problems in cardiology, 35, 72-115.

IUNG, B., VAHANIAN, A., NKOMO, V. T., GARDIN, J. M. & SKELTON, T. N. 2006. Burden of valvular heart diseases: a population-based study. Commentary. Lancet (British edition), 368.

KHUDHUR, A. M. & KADIR, D. H. 2022. An application of logistic regression modeling to predict risk factors for bypass graft diagnosis in Erbil. Cihan University-Erbil Scientific Journal, 6, 57-63.

KUSTERS, D. M., WIEGMAN, A., KASTELEIN, J. J. & HUTTEN, B. A. 2014. Carotid intimamedia thickness in children with familial hypercholesterolemia. Circ Res, 114, 307-10

LEWINGTON, S., WHITLOCK, G., CLARKE, R., SHERLIKER, P., EMBERSON, J., HALSEY, J., QIZILBASH, N., PETO, R. & COLLINS, R. 2007. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet, 370, 1829-39.

NAVAR-BOGGAN, A. M., PETERSON, E. D., D'AGOSTINO, R. B., SR., NEELY, B., SNIDERMAN, A. D. & PENCINA, M. J. 2015. Hyperlipidemia in early adulthood increases long-term risk of coronary heart disease. Circulation, 131, 451-8.

OTHMAN, G. Q., SAEED, R. S., KADIR, D. H. & TAHER, H. J. Relation of angiography to hematological, hormonal and some biochemical variables in coronary artery bypass graft patients. Journal of Physics: Conference Series, 2019. IOP Publishing, 062110

PANAGIOTAKOS, D. B. & TOUTOUZAS, P. K. 2003. Importance of LDL/HDL cholesterol ratio as a predictor for coronary heart disease events in patients with heterozygous familial hypercholesterolaemia: a 15-year follow-up (1987-2002). Current medical research and opinion, 19, 89-94.

SATOH, M., OHKUBO, T., ASAYAMA, K., MURAKAMI, Y., SUGIYAMA, D., WAKI, T., TANAKA-MIZUNO, S., YAMADA, M., SAITOH, S., SAKATA, K., IRIE, F., SAIRENCHI, T., ISHIKAWA, S., KIYAMA, M., OKAYAMA, A., MIURA, K., IMAI, Y., UESHIMA, H. & OKAMURA, T. 2021. A Combination of Blood Pressure and Total Cholesterol Increases the Lifetime Risk of Coronary Heart Disease Mortality: EPOCHJAPAN. J Atheroscler Thromb, 28, 6-24.

SINGH, I. M., SHISHEHBOR, M. H. & ANSELL, B. J. 2007. High-density lipoprotein as a therapeutic target: a systematic review. Jama, 298, 786-798.

TIROSH, A., RUDICH, A., SHOCHAT, T., TEKESMANOVA, D., ISRAELI, E., HENKIN, Y., KOCHBA, I. & SHAI, I. 2007. Changes in triglyceride levels and risk for coronary heart disease in young men. Ann Intern Med, 147, 377-85.

TSAO, C. W., ADAY, A. W., ALMARZOOQ, Z. I., ALONSO, A., BEATON, A. Z., BITTENCOURT, M. S., BOEHME, A. K., BUXTON, A. E., CARSON, A. P., COMMODORE-MENSAH, Y., ELKIND, M. S. V., EVENSON, K. R., EZE-NLIAM, C., FERGUSON, J. F., GENEROSO, G., HO, J. E., KALANI, R., KHAN, S. S., KISSELA, B. M., KNUTSON, K. L., LEVINE, D. A., LEWIS, T. T., LIU, J., LOOP, M. S., MA, J., MUSSOLINO, M. E., NAVANEETHAN, S. D., PERAK, A. M., POUDEL, R., REZKHANNA, M., ROTH, G. A., SCHROEDER, E. B., SHAH, S. H., THACKER, E. L., VANWAGNER, L. B., VIRANI, S. S., VOECKS, J. H., WANG, N. Y., YAFFE, K. & MARTIN, S. S. 2022. Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association. Circulation, 145, e153-e639.

TSENG, C. H., TSENG, C. P., CHONG, C. K., CHENG, J. C. & TAI, T. Y. 2006. Independent association between triglycerides and coronary artery disease in Taiwanese type 2 diabetic patients. Int J Cardiol, 111, 80-5.

UMEMURA, S., ARIMA, H., ARIMA, S., ASAYAMA, K., DOHI, Y., HIROOKA, Y., HORIO, T., HOSHIDE, S., IKEDA, S., ISHIMITSU, T., ITO, M., ITO, S., IWASHIMA, Y., KAI, H., KAMIDE, K., KANNO, Y., KASHIHARA, N., KAWANO, Y., KIKUCHI, T., KITAMURA, K., KITAZONO, T., KOHARA, K., KUDO, M., KUMAGAI, H., MATSUMURA, K., MATSUURA, H., MIURA, K., MUKOYAMA, M., NAKAMURA, S., OHKUBO, T., OHYA, Y., OKURA, T., RAKUGI, H., SAITOH, S., SHIBATA, H., SHIMOSAWA, T., SUZUKI, H., TAKAHASHI, S., TAMURA, K., TOMIYAMA, H., TSUCHIHASHI, T., UEDA, S., UEHARA, Y., URATA, H. & HIRAWA, N. 2019. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019). Hypertens Res, 42, 1235-1481.

ZVINTZOU, E., KARAMPELA, D. S., VAKKA, A., XEPAPADAKI, E., KARAVIA, E. A., HATZIRI, A., GIANNOPOULOU, P. C. & KYPREOS, K. E. 2021. High density lipoprotein in atherosclerosis and coronary heart disease: Where do we stand today? Vascul Pharmacol, 141, 106928.

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