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Research Article


Background and Objective: Addiction with Cannabis represents one of the major spreading phenomena worldwide. The objective of this study is to evaluate the oxidative stress enzyme markers and lipid peroxidation marker in cannabis administered female rats via intraperitoneal injection. MATERIALS AND METHODS: Thirty female rats were randomly allocated into three groups. First group regarded as control, while the animals of the second and third groups were daily injected intraperitoneally with (5 and 10 mg Cannabis/kg b.w.) for seven successive days. Enzymatic activities of alkaline phosphatase (ALP), Xanthine Oxidase (XO), Glucose-6- phosphate dehydrogenase (G6PDH) and lactate dehydrogenase (LDH) in serum were analyzed, and concentration of Malondialdehyde (MDA) was assayed. RESULTS: The activity of ALP, G6PDH and LDH significantly affected, whereas XO not affected. The lipid peroxidation marker; MDA significantly elevated in high dose treatment. CONCLUSION: This finding suggests that intraperitoneal injection of cannabis causes alterations in oxidation process

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