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Corresponding Author

Twana Ahmed Mustafa

Authors ORCID

0000-0001-6067-7695

Document Type

Research Article

Abstract

Vascular disease and heart attacks are a common phenomenon in the modern world, where lipid accumulates inside blood vessels and causes plug, eventually heart stroke and death. Utilize lipid-lowering drugs are the most effective factors to prevent heart disease. Atorvastatin is the most important drugs that used in this field. The aim of this study was to investigate the adverse effects of atorvastatin (20 mg/kg/b.wt/day) on some organs of albino. 12 adult male albino rats weighing 200 ± 20 g were used and divided into two groups: First group served as control group, was given 0.72 ml distilled water/rat. The second group was subjected to treatments with atorvastatin in a dose of 20 mg/kg/b.wt/day as a single daily dose (0.72 ml contained 1.44 mg of atorvastatin) orally by gastric tube for 4 weeks. Histological alterations were examined, and the results of atorvastatin-treated groups showed changes in the kidney sections, which include focal tubular edema and glomerular atrophy, also liver sections revealed foci of lymphocyte accumulation, cytoplasmic vacuolization, as well as sections of the testes showed degenerative changes in the seminiferous tubules.According to this study, we can conclude that atorvastatin-induced various deleterious changes in the histological structure of the testes, kidneys and cause mild liver alteration of adult male albino rat

Keywords

Atorvastatin, Kidney, Liver, Rats, Testis

Publication Date

4-10-2019

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